The NVIDIA PhysX SDK is in use in a wide range of games on all major gaming platforms (Advanced hardware features are available in select PC titles). Here is a partial list of PhysX Games::
| Game Title | Developer | Platform(s) |
| 2 Days to Vegas | Steel Monkeys | PC |
| Adrenalin 2: Rush Hour | Gaijin Entertainment | PC |
| Age of Empires III | Distineer Studios | Macintosh |
| Age of Empires III: The WarChiefs | Distineer Studios | Macintosh |
| Alpha Prime | Black Element Software | PC |
| Auto Assault | Net Devil | PC |
| Backbreaker | Natural Motion | TBA |
| B.A.S.E. Jumping | Digital Dimension Development | PC |
| Bet on Soldier: Blackout Saigon | Kylotonn Entertainment | PC |
| Bet on Soldier: Blood of Sahara | Kylotonn Entertainment | PC |
| Bet on Soldier: Blood Sport | Kylotonn Entertainment | PC |
| Captain Blood | Akella | PC, XBox 360 |
| Cellfactor: Combat Training | Artifical Studios, Immersion Games | PC |
| Cellfactor: Revolution | Artifical Studios, Immersion Games | PC |
| City of Villains | Cryptic Studios | PC |
| Crazy Machines II | FAKT Software | PC |
| Cryostasis | Action Forms | PC |
| Desert Diner | Tarsier Studios | PC |
| Dragonshard | Atari | PC |
| Dusk 12 | Orion | PC |
| Empire Above All | IceHill | PC |
| Empire Earth III | Mad Dog Software | PC |
| Entropia Universe | MindArk | PC |
| Fallen Earth | Icarus Studios | PC |
| Fury | Auran Games | PC |
| Gears Of War | Epic Games | XBox 360 |
| Gluk'Oza: Action | GFI Russia | PC |
| GooBall | Ambrosia software | Macintosh |
| Gothic 3 | Piranha Bytes | PC |
| Gunship Apocalypse | FAKT Software | PC |
| Heavy Rain | Quantic Dream | PC |
| Hero's Jorney | Simutronics | PC |
| Hour of Victory | nFusion Interactive | XBox 360 |
| Hunt, The | Orion | PC |
| Huxley | Webzen, Inc | PC, XBox 360 |
| Infernal | Metropolis Software | PC |
| Inhabited island: Prisoner of Power | Orion | PC |
| Joint Task Force | Most Wanted Entertainment | PC |
| Kuma\WAR | Kuma Reality Games | PC |
| Magic ball 3 | Alawar Entertaiment | PC |
| Mass Effect | BioWare | XBox 360 |
| Medal of Honor: Airborne | EA Los Angeles | PC, XBox 360 |
| Metro 2033 | 4A Games | PC |
| Mobile Suit Gundam: Crossfire | BEC | Playstation 3 |
| Monster Madness: Battle for Suburbia | Artificial Studios | PC, XBox 360 |
| Monster Truck Maniax | Legendo Entertainment | PC |
| Myst Online: URU Live | Cyan Worlds | PC |
| Open Fire | BlueTorch Studios | PC |
| Paragraph 78 | Gaijin Entertainment | PC |
| Pirates of the Burning Sea | Flying Lab Software | PC |
| PT Boats: Knights of the Sea | Akella | PC |
| Rail Simulator | Kuju Entertainment Ltd | PC |
| Red Steel | Ubisoft Paris | Wii |
| Rise Of Nations: Rise Of Legends | Big Huge Games | PC |
| Roboblitz | Naked Sky Entertainment | PC, XBox 360 |
| Sacred 2 | ASCARON Entertainment | PC |
| Sherlock Holmes: The Awakened | Frogwares Game Development Studio | PC |
| Showdown: Scorpion | B-COOL Interactive | PC |
| Silverfall | Monte Cristo | PC |
| Sovereign Symphony | Ceidot Game Studios | PC |
| Sonic and the Secret Rings | SEGA | Wii |
| Speedball 2 | Kylotonn Entertainment | PC |
| Stalin Subway, The | Orion | PC |
| Stoked Rider: Alaska Alien | Bongfish Interactive Entertainment | PC |
| Switchball | Atomic Elbow | PC |
| Tension | Ice-pick Lodge | PC |
| Tom Clancy's Ghost Recon Advanced Warfighter | GRIN | PC, XBox 360 |
| Tom Clancy's Ghost Recon Advanced Warfighter 2 | GRIN, Ubisoft Paris | PC, XBox 360 |
| Tom Clancy's Rainbow Six Vegas | Ubisoft Montreal | PC, XBox 360, Playstation 3 |
| Tom Clancy's Splinter Cell: Double Agent (multiplayer) | Ubisoft Shanghai | PC, XBox 360 |
| Tortuga: Two Treasures | Ascaron Entertainmenta | PC |
| Two Worlds | Reality Pump | PC |
| Ultra Tubes | Eipix | PC |
| Unreal Tournament 3 | Epic Games | PC, XBox 360, Playstation 3 |
| Warfare | GFI Russia | PC |
| Warmonger: Operation Downtown Destruction | Net Devil | PC |
| W.E.L.L. Online | Sibilant Interactive | PC |
| Winterheart's Guild | Zelian Games | PC, XBox 360 |
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